Article: Shape factor analysis as a quantitative framework for assessing spheroid and organoid morphology and invasiveness
'By enabling numerical morphological readouts, shape factor analysis can enhance phenotypic profiling of spheroids and organoids and provide valuable metrics for in vitro studies, including high-throughput and drug screening workflows'
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Schutrum BE, Deng J, Kim JH, Gao A, Hur E, Crowley JC, Ling L, Pirtz MG, Ralston CQ, Nikitin AY, Fischbach C. Shape factor analysis as a quantitative framework for assessing spheroid and organoid morphology and invasiveness. APL Bioeng. 2026 Jul 1;10(3):036101. doi: 10.1063/5.0333152. PMID: 42389052; PMCID: PMC13322776.
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