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A tumour-derived organoid biobank maps cancer gene dependencies

Includes video. This open, publicly available resource provides a systematic map of gene dependencies in patient-derived organoids, expanding the model diversity and mechanistic insight needed to advance precision oncology.
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Head of community, WORC.Community (A Caterpillar Hill Limited venture).
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Herranz-Ors C, Bhosle SG, Beck AE, Gilbert JGR, Picco G, Espejo Valle-Inclan J, Muyas F, Valentini S, Andres AE, Ansari R, Barthorpe S, Battarbee G, Beaver CM, Brocklesby S, Cantwell J, Collins CA, Davis J, Dimitrova HG, Doran J, Efendi E, Evans K, Fekry M, Fowler TA, Garcia-Casado M, Griffiths JAT, Hall C, Hamer R, Hardy C, Hewitson Z, Hitch E, Holland L, Jackson DA, Joshi N, Kavasakali A, Letchford L, Lightfoot HB, Lingala H, Mali I, May K, Mironenko T, Morris J, Pacini C, Price S, Robert-Tissot G, Rogers HA, Smith JV, Smith K, Souster E, Spence WJ, Thomas F, Vieira SF, Walker S, Alfonsin G, Bermingham H, Coles H, Ennis DP, Freeman A, Giannone G, Grehan N, Griffiths EA, Hall J, Lee SL, Leung EYL, Loreno C, Millington C, Mirnezami A, Nutzinger B, Orzechowska K, Pinna CMA, Redmond AM, Roberts K, Roy S, Sanders DA, Taniere P, Vias M, Wanigasooriya K; OCCAMS Consortium; Stratton MR, Staudt LM, McDermott U, Brenton JD, McNeish IA, Biankin A, Sansom OJ, Cortes-Ciriano I, Underwood TJ, Fitzgerald RC, Beggs AD, Francies HE, Garnett MJ. A tumour-derived organoid biobank maps cancer gene dependencies. Nature. 2026 Sep;657(8132):765-774. doi: 10.1038/s41586-026-10830-y. Epub 2026 Aug 5. PMID: 42557320; PMCID: PMC13581617.

Go to the profile of WORC Update
WORC Update (He/Him)
Head of community, WORC.Community (A Caterpillar Hill Limited venture).

Thank you for joining us here at WORC! This platform has the  sole purpose of bringing Organoid and Organ-on-a-chip researchers together! Easily connect, share content, ideas and experiences in this transformative area of science. The idea for this community came after speaking with many of you expressing the need for joined up thinking and making long lasting connections.

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