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Evaluation of Acute Exposure to Combustible and Novel Tobacco Products Using an In Vitro Human Airway Organ Tissue Equivalent Model

Exploring Next-Gen Tobacco Risks: Human 3D Airway Model Reveals How Heated and Electronic Products Differ from Cigarettes in Toxicity, Inflammation, and Airway Damage Under Nicotine-Matched Exposure

Nov 17, 2025

Suruchi Poddar

Postdoctoral Associate, Wake Forest University

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Citation: Leach, T. S., Albertson, S., Clapp, P. W., Surendran, V., Simon, T., Donny, E. C., Walker, S. J., Atala, A., & Murphy, S. V. (2025). Evaluation of Acute Exposure to Combustible and Novel Tobacco Products Using an In Vitro Human Airway Organ Tissue Equivalent Model. Journal of applied toxicology : JAT, 10.1002/jat.4971. Advance online publication. https://doi.org/10.1002/jat.4971

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Suruchi Poddar (She/Her)

Postdoctoral Associate, Wake Forest University

As much as I love doing research, I feel great aversion doing it at the cost of countless animals being sacrificed. Being a passionate advocate of ethical and sustainable research practices, I am fascinated by the idea of using alternative in vitro platforms to reduce and ultimately replace animal testing methodologies. While I acknowledge the historical significance of animal testing and the complex physiological interactions that they provide, I firmly believe that the rapid advancements in the field of biomedical research and development of in vitro testing platforms such as microphysiological systems, organoids, 3D bioprinting offer a more humane and robust approach for toxicological assessments.