Optimisation of an in vitro human cardiovascular model on-a-chip for toxicological assessment of nicotine delivery products


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Chapman F, de Haan L, Gijzen L, Strijker W,Sticken ET, Pour SJ, Wieczorek R, Haberstroh F,Otte S, Nahde T, Simms L and Stevenson M(2024), Optimisation of anin vitrohumancardiovascular model on-a-chip fortoxicological assessment of nicotinedelivery products.Front. Toxicol.6:1395670.doi: 10.3389/ftox.2024.1395670COPYRIGHT© 2024 Chapman, de Haan, Gijzen, Strijker,Sticken, Pour, Wieczorek, Haberstroh, Otte,Nahde, Simms and Stevenson. This is an open-access article distributed under the terms of theCreative Commons Attribution License (CC BY).The use, distribution or reproduction in otherforums is permitted, provided the originalauthor(s) and the copyright owner(s) arecredited and that the original publication in thisjournal is cited, in accordance with acceptedacademic practice. No use, distribution orreproduction is permitted which does notcomply with these terms.Abbreviations:ANOVA, Analysis of variance; bPBS, Bubbled phosphate buffered saline (solution); ECM,Extracellular matrix; ENDS, Electronic nicotine delivery system; GSH: Glutathione; HBSS, HanksBalanced Salt Solution; HCAEC, Human Coronary Artery Endothelial Cells; HCI, High contentimaging; HEPES, N-(2-Hydroxyethyl)piperazine-N-(2-ethanesulfonic acid); HPHCs, Harmful andpotentially harmful constituents; HTP, Heated tobacco product; ICAM-1, Immunoglobulin celladhesion molecule-1; ISO, International Organization for Standardization; LOQ, Limit ofquantification; NGP, Next-generation nicotine delivery product; ns, Not significant; Papp, Apparentpermeability; PBS, Phosphate buffered saline (solution); RPMI, Roswell Park Memorial Institute (cellculture medium); THR, Tobacco harm reduction; TRITC, tetramethylrhodamine isothiocyanate; VCAM-1, Vascular cell adhesion molecule-1; WST-8, Water-soluble tetrazolium salt.Frontiers inToxicologyfrontiersin.org01TYPEOriginal ResearchPUBLISHED13 June 2024DOI10.3389/ftox.2024.1395670

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