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Characterizing pancreatic cancer-associated fibroblast heterogeneity in vascular microphysiological systems

This work provides novel insights into the heterogeneous functions of CAFs in the TME and lays important groundwork for the development of CAF-targeted therapies in PDAC.
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Blackledge CW, Gullion S, McCabe I, Van NNK, Hariharan A, Luan C, Peng XL, Polacheck WJ, Yeh JJ, Shelton SE. Characterizing pancreatic cancer-associated fibroblast heterogeneity in vascular microphysiological systems. Angiogenesis. 2026 Jun 9;29(3):39. doi: 10.1007/s10456-026-10061-9. PMID: 42265391.

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