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Tirzepatide Regulates Pacemaker Function by Modulating cAMP and Calcium Dynamics in Human Sinoatrial Node Cells

(Using generated human iPSC-derived sinoatrial node cells and 3D iPSC-derived pacemaker organoids).
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Tirzepatide Regulates Pacemaker Function by Modulating cAMP and Calcium Dynamics in Human Sinoatrial Node Cells
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Ren L, Belbachir N, Zhang H, Thai PN, Huang R, Zhu W, Wu X, Xie M, Gao J, Kim HY, Liu T, Sun J, Ghazizadeh Z, Navedo MF, Wu JC. Tirzepatide Regulates Pacemaker Function by Modulating cAMP and Calcium Dynamics in Human Sinoatrial Node Cells. Circulation. 2026 Jun 23;153(25):2110-2113. doi: 10.1161/CIRCULATIONAHA.125.076669. Epub 2026 Jun 22. PMID: 42330097; PMCID: PMC13288756.

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