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Transferrin-Functionalized Liposomes Enhance MAPT-ASO Transport Across a 3D Blood–Brain Barrier Microvascular Network Model.

We tested liposome-mediated drug delivery in a blood-brain barrier-on-a-chip in vitro model with 3D self-assembled microvasculature formed by human brain endothelial cells, astrocytes, and pericytes.
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Simon Konig
PhD student, University College London
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Topics: Organ-on-a-chip, Hydrogel, Drug delivery, Blood-Brain Barrier, Liposomes, Alzheimer's disease, Antisense oligonucleotides.

Citation: Konig, S.; Shen, X.; Mantovani, G.; Winkler, G.S.; Zhu, Z.; Moeendarbary, E. Transferrin-Functionalized Liposomes Enhance MAPT-ASO Transport Across a 3D Blood–Brain Barrier Microvascular Network Model. Int. J. Mol. Sci. 2025, 26, 11347. https://doi.org/10.3390/ijms262311347

Go to the profile of Simon Konig
Simon Konig
PhD student, University College London

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