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MDPI Organoids, Volume 4, Issue 1 (March 2025) – 6 articles

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Volume 4 articles below.

Also, now accepting applications to be in the special edition with WORD+ speakers: Organoid and Organ-on-a-Chip Research Advances in 2025: View.

The Intestinal Stem Cell Niche: Generation and Utilization of Intestinal Organoids

by Toshio Takahashi andYuta Takase
Organoids 2025, 4(1), 6; https://doi.org/10.3390/organoids4010006 - 20 Mar 2025
Abstract 
In cell biology, the stem cell niche is the dynamic microenvironment in which stem cells reside and receive signals that determine their behavior and fate. The stem cell niche has largely been a theoretical construct due to the difficulty in identifying and manipulating [...] Read more.

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Breast Cancer Tissues and Organoids BioBank: Constitution, Research Activities and Samples Access

by Lucia Miranda,Luigi Mandrich,Simona Massa,Teresa Nutile,Clotilde Crovella,Ilaria De Rosa,Raffaella Lucci,Filippo De Rosa,Pasquale Somma,Vincenzo Mercadante,Ciro Abate,Salvatore Arbucci,Luigi Panico andEmilia Caputo
Organoids 2025, 4(1), 5; https://doi.org/10.3390/organoids4010005 - 3 Mar 2025

Abstract 

In 2023, at the Center for Biological Resources (CRB) at the Institute of Genetics and Biophysics (IGB, Naples, Italy) of the National Research Council (CNR), the Breast Cancer Tissues and Organoids Biobank (BCTO BioBank) was founded. This is a new generation Biobank, dedicated [...] Read more.
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Paneth Cells Are a Constitutive Source of IL-10 in Mouse Small Intestinal Organoids
by Huong Nguyen,Francesca Di Cara,Jun Wang andAndrew W. Stadnyk
Organoids 2025, 4(1), 4; https://doi.org/10.3390/organoids4010004 - 12 Feb 2025

Abstract 
The healthy gut masks a dynamic balance between pro- and anti-inflammatory activities, largely due to microbial factors in the lumen. IL-10 is vital among the anti-inflammatory mediators, yet confirming constitutive versus stimulated secretion in any cell type is difficult due to the cellular [...] Read more.
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Establishment of Intestinal Organoids from Common Marmosets
by Arisa Ishimura,Ken Iwatsuki andHiroo Imai
Organoids 2025, 4(1), 3; https://doi.org/10.3390/organoids4010003 - 12 Feb 2025

Abstract 
Intestinal organoids are useful for the in vitro investigation of the properties of intestinal epithelial cells and their interaction with the gut microbiome. In this study, we cultured cecal and colonic organoids from common marmosets, which are highlighted as model nonhuman primates but [...] Read more.
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Precision Medicine for Peritoneal Carcinomatosis—Current Advances in Organoid Drug Testing and Clinical Applicability
by Harleen Kaur,Josephine A. Wright,Daniel L. Worthley,Elizabeth Murphy andSusan L. Woods
Organoids 2025, 4(1), 2; https://doi.org/10.3390/organoids4010002 - 24 Jan 2025

Abstract 
Peritoneal carcinomatosis from gastrointestinal tumours is considered a poor prognostic factor, with a median overall survival of six to nine months in the absence of intervention. The advent of patient-derived organoid cultures (PDOs) has provided a breakthrough in personalised medicine, allowing researchers and [...] Read more.
(This article belongs to the Special Issue Advances in Organoid Technology: Bridging the Gap between Research and Therapy)
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Three-Dimensional Morphological Characterisation of Human Cortical Organoids Using a Customised Image Analysis Workflow
by Sarah Handcock,Kay Richards,Timothy J. Karle,Pamela Kairath,Alita Soch,Carolina A. Chavez,Steven Petrou andSnezana Maljevic
Organoids 2025, 4(1), 1; https://doi.org/10.3390/organoids4010001 - 17 Jan 2025

Abstract 
Summary Statement: A tailored image analysis workflow was applied to quantify cortical organoid health, development, morphology and cellular composition over time. The assessment of cellular composition and viability of stem cell-derived organoid models is a complex but essential approach to understanding the [...] Read more.
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