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Comparative Evaluation of hiPSC-Derived Brain Organoids as Platforms for Assessing Thyroid Hormone System Disrupting Chemicals

Together, these findings provide a framework for organoid qualification-linking TH handling, transcriptomic responsiveness, and scalable phenotypic readouts-as a necessary step toward model validation and implementation of brain organoids in THSDC risk assessment pipelines.'
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Fernandez Vallone V, Hellwig L, Rijntjes E, von Kügelgen N, Sane R, Opitz R, Kühnen P, Köhrle J, Mergenthaler P, Stachelscheid H. Comparative Evaluation of hiPSC-Derived Brain Organoids as Platforms for Assessing Thyroid Hormone System Disrupting Chemicals. Cells. 2026 May 22;15(11):963. doi: 10.3390/cells15110963. PMID: 42274556.

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WORC Update (He/Him)
Head of community, WORC.Community (A Caterpillar Hill Limited venture).

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