Liver-on-Micropillar: a humanized, animal-free platform for high-throughput assessment of drug-induced liver injury

Revolutionizing Hepatotoxicity Testing: A Fully Xeno-Free Liver-on-Micropillar (LoM) Platform Delivers Scalable, Human-Relevant, High-Throughput Screening with 90% Predictive Accuracy for Drug-Induced Liver Injury—Paving the Way Toward Ethical, Non-Animal Drug Safety Evaluation
Go to the profile of Suruchi Poddar
Suruchi Poddar
Postdoctoral Associate, Wake Forest University
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Citation : Ahmed S M Ali et al 2025 Biofabrication 17 045022 DOI 10.1088/1758-5090/ae1063

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Go to the profile of Suruchi Poddar
Suruchi Poddar (She/Her)
Postdoctoral Associate, Wake Forest University

As much as I love doing research, I feel great aversion doing it at the cost of countless animals being sacrificed. Being a passionate advocate of ethical and sustainable research practices, I am fascinated by the idea of using alternative in vitro platforms to reduce and ultimately replace animal testing methodologies. While I acknowledge the historical significance of animal testing and the complex physiological interactions that they provide, I firmly believe that the rapid advancements in the field of biomedical research and development of in vitro testing platforms such as microphysiological systems, organoids, 3D bioprinting offer a more humane and robust approach for toxicological assessments.

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